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Saturday, December 26, 2009

[diabetes_int] Digest Number 8508

Messages In This Digest (2 Messages)

Messages

1a.

Re: Is Nicotinamide Overload a Trigger for Type 2 Diabetes?

Posted by: "whimsy2" whimsy2@hevanet.com   vabbott1

Fri Dec 25, 2009 6:50 am (PST)



Bruno, can you give me a link to the original research article?
Vicki

----- Original Message -----
From: "Bruno M." <brunom1@telenet.be>
To: <diabetes_int@yahoogroups.com>
Sent: Thursday, December 24, 2009 11:06 AM
Subject: [diabetes_int] Is Nicotinamide Overload a Trigger for Type 2
Diabetes?

FYI:
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
www.sciencedaily.com/releases/2009/12/091222105449.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29

Is Nicotinamide Overload a Trigger for Type 2 Diabetes?

ScienceDaily (Dec. 24, 2009) ­ Facing the increasing prevalence of type
2 diabetes worldwide in the past few decades, one may ask what is wrong
with humans. Geneticists tell us that the human genome has not changed
markedly in such a short time. Therefore, something must be happening in
our environment or diet. As a matter of fact, dietary pattern is known
to be closely linked to the development of type 2 diabetes. The
increasing prevalence of type 2 diabetes following worldwide food
fortification with niacin suggests that type 2 diabetes may involve
excessive niacin intake.

research article to be published on December 7, 2009 in the World
Journal of Gastroenterology addresses the association between
nicotinamide overload and type 2 diabetes. The study revealed that
diabetic patients have a slow nicotinamide metabolism and thus require a
longer time to clear up excess nicotinamide metabolites within the body.

High nicotinamide intake may lead to an increase the generation of
reactive oxygen species, and subsequent oxidative stress and insulin
resistance, both being the major features of type 2 diabetes. Liver is
the main organ responsible for nicotinamide detoxification. This study
found that liver-injury-inducing drugs may reduce nicotinamide
detoxification and thus impair glucose tolerance.

Most interestingly and importantly, this study demonstrates that
sweating is an effective way for expelling excess nicotinamide from the
body. The findings from this study may help explain a wide variety of
well-documented but poorly understood phenomena in diabetes, such as
lifestyle-triggered diabetes, liver-disease-related abnormal glucose
metabolism, post-burn insulin resistance, and seasonal diabetes.

Nowadays, the high prevalence of type 2 diabetes may be due to both too
much niacin in our foods and too little excretion through our sweat
glands. The so-called gene-environment interaction in type 2 diabetes
may actually be the outcome of the association of excess niacin intake
and relatively low detoxification and excretion from the body, says lead
author Dr. Shi-Sheng Zhou, Professor of the Institute of Basic Medical
Sciences of Dalian University.

Historically, niacin deficiency was restricted mainly to those with poor
nutrition who performed heavy industrial labor. Hence, this study gives
rise to an important social and public health issue whether foods need
to be fortified with niacin any more, when the people in developed
countries have already been living in an age of over-nutrition. The
authors found that reducing nicotinamide intake and facilitating the
excretion of nicotinamide metabolites may be a useful preventive and
therapeutic intervention in type 2 diabetes.

The peer reviewers stated that it is an interesting study with human and
experimental data, which investigated a clinically relevant issue, and
gave an insight into the pathogenic mechanisms involved.
=======================================================

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2.

Re: Too much niacin gives you type 2 diabetes?

Posted by: "Joseph Navarro" demokratia@cox.net   demokratia2003

Fri Dec 25, 2009 11:31 am (PST)



This is probably the best accessible article on the subject:

http://www.wjgnet.com/1007-9327/15/5674.asp

Here is a less technical chat:

http://www.diabetessymptomsonline.com/forums/showthread.php?t=1018

Such incredible conclusions from a study of 14 diabetics and 14
non-diabetics. The mainland Chinese are the researchers who ask if
excess niacin is the source of type 2 diabetes? The food our food
corporations are distributing throughout the globe is having
devastating effects on third world countries. It has devastated
native Indians more perhaps than the diseases Europeans brought to
the new world earlier. Today's kids have access to unlimited amounts
of candy and carbohydrates that overwhelm the insulin requirements of
excessive ingestion of carbs. The excess may have transformed them
into unheard of diabetics, diabetics in their childhood. Of course,
corporations who want to sell their product are active in stifling
any information that harms the sale of their product and if you see
Food, Inc. an incredible documentary on today's food you will learn
that the food industry has started to use their lawyers to make any
criticism of their products, especially as to how that criticism
affects sales illegal. Oprah got a taste of that.

Usually the cause of anything, assuming there is a casual
relationship, involves more than one variable. It is fashionable
these days to assume genetics is behind most disease, it sort of
justifies using chemicals on mental patients and saving tax money on
non-chemical modes of treatment. Not that spending lots of money on
mental patients is at the heart of their care: in third world
countries mental patients tend to get well because they are treated
with love and not as freaks. The figure we honor in today's holiday
said:

"For I was hungry and you gave me something to eat, I was thirsty and
you gave me something to drink, I was a stranger and you invited me
in, I needed clothes and you clothed me, I was sick and you looked
after me, I was in prison and you came to visit me.

Lord, when did we see you hungry and feed you, or thirsty and give
you something to drink? When did we see you a stranger and invite you
in, or needing clothes and clothe you? When did we see you sick or in
prison and go to visit you?

I tell you the truth, whatever you did for the least among you, you
did it to me."

Maybe this should be read in the Senate before fighting over health care?

Returning to the topic at hand:
Just the logic of saying or thinking any one thing is the cause of
anything is flawed reasoning. Here the gene-environment relationship
is linked with niacin and its metabolism and asking it seems more
than assuming from such a limited study of 14 diabetics and 14 who
are not diabetics if the niacin generates type 2 diabetes?

The Chinese have been making lots of money internationally but I
guess having so many mouths to feed severely limits their research
funding. In any case, this article does not strike me as being
impressive yet I can not accuse it of trying to promote the sale of
anything.

Please pardon my excursions and best wishes for Chirstmas,

Joe

=============================================================

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